TRPV1 Channels Contribute to Behavioral Hypersensitivity and Spontaneous Activity in Nociceptors After Spinal Cord Injury
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چکیده
iv Table of contents vi List of illustrations xi List of abbreviations xiv Chapter 1 --Introduction 1.1. Spinal cord injury induces chronic pain 1 1.2. Neurobiology of neuropathic pain 2 1.3. Multiple sites are altered after SCI, including DRG 5 1.4. Hyperexcitability of primary nociceptors appears to be an important mechanism underlying chronic pain after SCI 8 1.5. TRPV1 in nociceptors is potentially involved in SCI chronic pain 11 1.6. Several factors modulating TRPV1 channels are elevated after spinal cord injury 13 1.7. TRPV1 antagonists may block SCI chronic pain 15 1.8. Hypothesis 17 Chapter 2 --Material & Methods 2.1. Animals 19 2.2. Spinal cord injury 19
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تاریخ انتشار 2017